di erentiation between soft-tissue infections, as well as the
identification of the o ending agent, is mandatory, but the
o ending source needs to be identified, particularly for
the patient’s benefit, to prevent future events. Dermatitis with
the use of Neosporin ointment over an extended period of time
is almost always universal and resolves with cessation 14
( Fig. 21.4).
21.1.4 Chondritis
Auricular chondritis is a potentially significant complication, is
di cult to treat, and can cause long-term disfigurement.15,16
Occurring even late in the postoperative course, it requires iden-
tification and appropriate treatment, often inpatient intravenous
antibiotic therapy.15,16 The avascular involved cartilage is more
susceptible to bacterial infection and antibiotic therapy is less
e ective. Involved organisms are commonly Pseudomonas
aeruginosa and Staphylococcus aureus.17 E ective antimicrobial
management includes accurate identification of the organism
and antibiotic selection that provides appropriate antimicrobial
coverage and adequate tissue penetration ( Fig. 21.5).
Fig. 21.1 Hematoma requiring re-operation and evacuation.
Fig. 21.2 A 75-year-old male 1 month status post meshed Integra placement for scalp wound with exposed bone. Fibrinous exudate illustrated is
consistent with characteristic of normal wound healing with Integra and is not an infectious process. Exudate is removed and split-thickness skin graft
is performed as planned with 100% graft take. Results shown at 2 weeks.
Fig. 21.3 A 48-year-old female 2 days status post-bilobed flap
reconstruction of nasal tip Mohs defect. She developed postoperative
infection that was treated with a course of oral antibiotics. Final results
shown at 1 month with no negative sequelae as a result of the
infection.
Management of Complications in the Acute Healing Stage
183
Fig. 21.4 A 78-year-old male with classic dermatitis from topical antibiotic ointment use with previous sensitivity. Rash rapidly resolved with cessation
of topical ointment with no long-term sequelae.
Fig. 21.5 A 58-year-old male patient with ear chondritis after Mohs resection and attempted secondary healing. Treatment required intravenous
antibiotics with multidrug coverage for Pseudomonas aeruginosa. Results shown at 2 months with no sequelae.
Management of Complications and Revisions
184
21.1.5 Flap Failure
The absolute flap failure is gratifyingly rare, but when it does
occur the reason for its loss needs to be accurately determined.
For a surgeon, losing one flap is devastating, but losing a second
“rescue” flap is an order of magnitude more devastating for the
patient as it is frequently the last chance at a reasonable recon-
struction that is lost. Evaluation of a flap in jeopardy during the
immediate postoperative period should include patient assess-
ment and removal of any flap dressings that may contribute to
venous or arterial compression. Additionally, evaluation of the
flap pedicle to ensure no compression and removal of a portion
of the inset sutures may promote flap survival.
For flaps with venous congestion, the use of topical nitrogly-
cerin ointment is beneficial, as is the use of leech therapy, but
the utilization of hyperbaric oxygen or intravenous anticoagu-
lants is of questionable benefit and of significant expense.14,18
With flap failure, if it occurs, the decision on secondary recon-
struction needs to be made with careful identification of the
reason for the initial failure.
Many pedicled flaps that show distal flap tip loss can be con-
verted to a successful reconstruction by simple debridement
and flap re-advancement ( Fig. 21.6 and Fig. 21.7).
Wound Disruption
Something that occurs infrequently, but is devastating w hen
it does, is complete wound disruption or flap disruption
from inset pedicled flaps or local flaps. If it is from a trau-
matic injury, a fall, or actual disruption, the best results will
be obtained from returning the patient to the operating
room , thoroughly cleaning and debriding the wound to clean
healthy bleeding tissue, and then re-insetting it as it was
done initially ( Fig. 21.8).
Fig. 21.6 A 70-year-old female patient with partial flap loss after “Dallas design” forehead flap. This flap design is inherently poor because it converts
an axial-pattern flap unnecessarily to a random pattern flap. Additionally, the transverse brow incision both irreversibly elevates the contralateral
eyebrow and renders the contralateral brow useless for a rescue flap. Reconstruction was salvaged by flap revelation and advancement. Final results
shown at 5 months.
Management of Complications in the Acute Healing Stage
185
Fig. 21.8 A 63-year-old male patient with
hemiagnosia due to brain tumor. He presented
with posterior alar defect caused by nasogastric
tube-induced necrosis. He initially underwent
posterior alar repair with nasolabial flap. The flap
was subsequently disrupted by the patient.
Nasolabial flap was debrided and re-attached and
ultimately failed. An ill-advised forehead flap was
then performed and was also disrupted twice by
the patient. Flap ultimately failed.
Fig. 21.7 A 77-year-old female status post with poorly designed and executed cervical facial flap reconstruction of large cheek Mohs defect. Inevitable
flap failure with partial loss. Reconstruction salvaged with color-matched full-thickness skin graft. Final results shown at 4 months.
Management of Complications and Revisions
186
References
[1] Alam M, Ibrahim O, Nodzenski M, et al. Adverse events associated with Mohs
micrographic surgery: multicenter prospective cohort study of 20,821 cases
at 23 centers. JAMA Dermatol. 2013; 149(12):1378–1385
[2] Kirkorian AY, Moore BL, Siskind J, Marmur ES. Perioperative management of
anticoagulant therapy during cutaneous surgery: 2005 survey of Mohs sur-
geons. Dermatol Surg. 2007; 33(10):1189–1197
[3] Nast A, Rosumeck S, Erdmann R, Dressler C, Werner RN. Current guidelines in
dermatology: a selection of clinically relevant recommendations. Hautarzt.
2016; 67(5):391–396
[4] Larson RJ, Aylward J. Evaluation and management of hypertension in the
perioperative period of Mohs micrographic surgery: a review. Dermatol Surg.
2014; 40(6):603–609
[5] Zoumalan R, Rizk SS. Hematoma rates in drainless deep-plane face-lift sur-
gery with and without the use of fibrin glue. Arch Facial Plast Surg. 2008; 10
(2):103–107
[6] Delaney A, Diamantis S, Marks VJ. Complications of tissue ischemia in derm a-
tologic surgery. Dermatol Ther (Heidelb). 2011; 24(6):551–557
[7] Esposito S, Bassetti M, Bonnet E, et al. International Society of Chemotherapy
(ISC). Hot topics in the diagnosis and management of skin and soft-tissue
infections. Int J Antimicrob Agents. 2016; 48(1):19–26
[8] McClain SL, Bohan JG, Stevens DL. Advances in the medical management of
skin and soft tissue infections. BMJ. 2016; 355:i6004
[9] Russo A, Concia E, Cristini F, et al. Current and future trends in antibiotic ther-
apy of acute bacterial skin and skin-structure infections. Clin Microbiol Infect.
2016; 22 Suppl 2:S27–S36
[10] Sukumaran V, Senanayake S. Bacterial skin and soft tissue infections. Aust
Prescr. 2016; 39(5):159–163
[11] Furue M, Chiba T, Tsuji G, et al. Atopic derm atitis: immune deviation, barrier
dysfunction, IgE autoreactivity and new therapies. Allergol Int. 2017 Jul;
66(3):398–403
[12] Petry V, Bessa GR, Poziomczyck CS, et al. Bacterial skin colonization and infec-
tions in patients with atopic dermatitis. An Bras Dermatol. 2012; 87(5):729–
734
[13] Spałek M. Chronic radiation-induced derm atitis: challenges and solutions.
Clin Cosmet Investig Dermatol. 2016; 9:473–482
[14] Childs DR, Murthy AS. Overview of wound healing and management. Surg
Clin North Am. 2017; 97(1):189–207
[15] Sandhu A, Gross M, Wylie J, Van Caeseele P, Plourde P. Pseudomonas aerugi-
nosa necrotizing chondritis complicating high helical ear piercing case
report: clinical and public health perspectives. Can J Public Health. 2007; 98
(1):74–77
[16] Sosin M, Weissler JM, Pulcrano M, Rodriguez ED. Transcartilaginous ear pierc-
ing and infectious complications: a systematic review and critical analysis of
outcomes. Laryngoscope. 2015; 125(8):1827–1834
[17] Liu ZW, Chokkalingam P. Piercing associated perichondritis of the pinna: are
we treating it correctly? J Laryngol Otol. 2013; 127(5):505–508
[18] Erba M, Jungreis CA, Horton JA. Nitropaste for prevention and relief of vascu-
lar spasm. AJNR Am J Neuroradiol. 1989; 10(1):155–156
Management of Complications in the Acute Healing Stage
187
22 Management of Complications in the Late Healing Stage
James F. Thornton and Jourdan A. Carboy
Sum m ary
The management of complications in the late healing stage
including hyper- and hypopigmentation as well as contour
abnormalities is discussed. Treatment modalities including der-
mabrasion, laser therapy, steroid injection, and surgical revision
are outlined. The identification of cancer recurrence after Mohs
resection is also described.
Keywords: hypertrophic, hypopigmentation, hyperpigmenta-
tion, dermabrasion, cancer recurrence, contour abnormalities,
laser therapy, steroid injection
Summary
● Hyperpigmentation can be common with full-thickness
skin grafts that have prolonged healing. Dermabrasion
and/or laser therapy is very e cacious in improving final
appearance.
● Hypopigmentation is often unpredictable in occurrence and
di cult to correct.
● The treatment of contour abnormalities begins with e ective
scar management including massage, silicone sheeting, and
intralesional triamcinolone. If contour abnormalities are not
resolved with final scar maturation, then revision surgery is
indicated.
● Although rare in postoperative Mohs patients, practitioners
must remain vigilant about the possibility of cancer recur-
rence.
22.1 General Considerations
The management of complications in the late healing stage
involves poor color match of the flap or graft, poor contour of
the flap or graft, unexpected hypertrophic or keloid scarring of
the flap or graft, as well as functional issues such as nasal air-
way obstruction or lip ectropion and then finally cancer recur-
rence after the initial resection. Unfortunately, the management
of late complications also encompasses the management of
suboptimal results from the patient’s perspective. These can
either be true suboptimal surgical results or failure of the
patient’s expectations matching expected surgical results. Pa-
tient education can obviate and minimize many of the expected
results. A perfectly fine and acceptable, even very good, surgical
result can be viewed by the patient as an abject disaster if their
expectations do not match the surgical reality. It is foolish of the
surgeon and of low yield to continue to point out “how good”
the results are if the patient remains unhappy. Education with
time spent discussing the procedure, as well as the patient’s per-
ception of the results that include representative postoperative
photographs, is time well spent. Additionally, a second opinion
can also help temper this often di cult clinical situation.
22.1.1 Hypo- and Hyperpigmentation
The management of color complications can be hypo- or hyper-
pigmentation. More commonly, hyperpigmentation with
healed full-thickness skin grafts or flaps is often the result of
continued surface desquamation despite adequate graft take,
and this will require multiple episodes of dermabrasion to
improve the final color.1,2 Laser has some proven benefit and
pulsed-dye laser can commence as early as 6 weeks after graft
inset, often in conjunction with dermabrasion. The manage-
ment of hypopigmentation is more di cult and its occurrence
is somewhat unpredictable even with good graft take. Well-
vascularized healthy grafts may have a period of transient
hypopigmentation that corresponds to the absent vasomotor
function, but this will be restored as the vasomotor function
returns. Unfortunately, some hypopigmentation will never
resolve and long-term management of can be di cult
( Fig. 22.1 and Fig. 22.2).
22.1.2 Contour Abnormalities
Unacceptable contour abnormalities are initially managed with
rigorous postoperative scar therapy including silicone sheeting
and massage.3,4 If there is a hypertrophic scar component to
this, then intralesional triamcinolone on a scheduled injection
series is added to the treatment protocol.5,6 No attempt is made
to revise contour abnormalities until the graft or flap repair has
entered the supple healing stage and the skin is pliable.
Depressed contour abnormalities in the late healing stage are
fairly easily managed by flap re-elevation and placement of a
Fig. 22.1 Hyperpigmentation.
Management of Complications and Revisions
188
dermal fat graft, cartilage graft, or fat grafting.7,8,9 The manage-
ment of hypertrophic or keloid scars depends on the accurate
identification of either. Keloid scars can be tremendously di -
cult to manage and with simple excision alone or simple steroid
injection alone show an unacceptable (as high as 90%) recur-
rence rate.6,10,11 Multimodal therapy, including surgical excision
and intralesional steroids with or without mitomycin, is the
only acceptable management for keloid therapy.6,10,11 Recurrent
keloids are best managed by multimodality therapy that
includes surgical excision and immediate short-term radiation
therapy.6,10,11 Simpler to manage are hypertrophic scars and the
management should include a patient discussion that everyone
heals along a continuum and hypertrophic scars are a normal
portion of this continuum. Aggressive management should
include silicone sheeting, scar massage, as well as scheduled
intralesional steroid therapy10,12 ( Fig. 22.3).
22.1.3 Cancer Recurrence
Cancer recurrence is gratifyingly rare in post-Mohs patients;
however, it should always be kept in mind as an etiology for
poor contour abnormalities or recurrent skin lesions surround-
ing the repair. Remember that cancer recurrence is always at
the forefront of the patient’s mind and there is no greater per-
ceived catastrophe in treating cancer recurrence as a hypertro-
phic scar over a period of 3 to 6 months. Understand that in a
high-volume Mohs repair practice, even though the actual rate
of recurrence is very low, the surgical practitioner will see sev-
eral episodes yearly of cancer recurrence. The simplest solution
is a punch biopsy of any suspected lesions, or, if a patient
returns to the operating room for a revision procedure, then
biopsy and submission of pathologic specimens at the time
( Fig. 22.4a, b).
Fig. 22.2 Hypopigmentation.
Fig. 22.3 Hypertrophic scars.
Management of Complications in the Late Healing Stage
189
References
[1] Chan JC, Shek SY, Kono T, Yeung CK, Chan HH. A retrospective analysis on the
management of pigmented lesions using a picosecond 755-nm alexandrite
laser in Asians. Lasers Surg Med. 2016; 48(1):23–29
[2] Sofen B, Prado G, Emer J. Melasma and post inflammatory hyperpigmenta-
tion: management update and expert opinion. Skin Therapy Lett. 2016; 21
(1):1–7
[3] Alberti LR, Vicari EF, De Souza Jardim Vicari R, Petroianu A. Early use of CO2
lasers and silicone gel on surgical scars: Prospective study. Lasers Surg Med.
2017
[4] Commander SJ, Chamata E, Cox J, Dickey RM, Lee EI. Update on postsurgical
scar management. Semin Plast Surg. 2016; 30(3):122–128
[5] Davison SP, Dayan JH, Clemens MW, Sonni S, Wang A, Crane A. E cacy of
intralesional 5-fluorouracil and triamcinolone in the treatment of keloids.
Aesthet Surg J. 2009; 29(1):40–46
[6] Del Toro D, Dedhia R, Tollefson TT. Advances in scar management: prevention
and management of hypertrophic scars and keloids. Curr Opin Otolaryngol
Head Neck Surg. 2016; 24(4):322–329
[7] Gutiérrez Santamaría J, Masiá Gridilla J, Pamias Romero J, Giralt López-de-
Sagredo J, Bescós Atín MS. Fat grafting is a feasible technique for the sequelae of
head and neck cancer treatment. J Craniomaxillofac Surg. 2017; 45(1):93–98
Fig. 22.4 (a) An 81-year-old male presented 1 to 2 years status post Mohs excision of basal cell carcinoma at dorsal nose that was allowed to heal
secondarily. He returned with a present lesion that measured 1.2 cm × 1.3 cm. Biopsy of the lesion revealed basal cell carcinoma. The working
diagnosis was recurrent basal cell carcinoma. Two stages of Mohs surgery required to achieve clear margins (defect = 2.0 × 2.3 cm). Final repair was
done with dorsal nasal rotation flap. (b) A 78-year-old male presented 1 year status post Mohs excision for squamous cell carcinoma. Current lesion
present for approximately 8 months with crusting, itching, and rapid growth. The lesion measured 0.5 cm × 0.7 cm (not counting linear scar that was
also excised with Mohs stage). Biopsy of the lesion revealed squamous cell carcinoma. The working diagnosis is squamous cell carcinoma. One stage of
Mohs surgery required resulting in defect measuring 2.5 × 2.5 cm.
Management of Complications and Revisions
190
[8] Levy LL, Zeichner JA. Management of acne scarring, part II: a comparative
review of non-laser-based, minimally invasive approaches. Am J Clin Derma-
tol. 2012; 13(5):331–340
[9] Thomas JR, Somenek M. Scar revision review. Arch Facial Plast Surg. 2012; 14
(3):162–174
[10] Heppt MV, Breuninger H, Reinholz M, Feller-Heppt G, Ruzicka T, Gauglitz GG.
Current strategies in the treatment of scars and keloids. Facial Plast Surg.
2015; 31(4):386–395
[11] Khan MA, Bashir MM, Khan FA. Intralesional triamcinolone alone and in com-
bination with 5-fluorouracil for the treatment of keloid and hypertrophic
scars. J Pak Med Assoc. 2014; 64(9):1003–1007
[12] Khansa I, Harrison B, Janis JE. Evidence-based scar management: how to
improve results with technique and technology. Plast Reconstr Surg. 2016;
138(3) Suppl:165S–178S
Management of Complications in the Late Healing Stage
191
23 Skin Graft Revisions
James F. Thornton and Jourdan A. Carboy
Sum m ary
The management of skin graft complications in both the acute
and late healing stages is discussed. The management of
contour abnormalities, both concavities and convexities, is
outlined.
Keywords: skin graft, full-thickness skin graft, fat grafting,
cartilage graft, dermabrasion
Summary
● Even though on initial postoperative visits skin grafts are
often marginal in appearance, they very rarely need
complete revision once healed.
● Skin graft contour abnormalities are most commonly
concavity and can be relatively easily corrected with dermal
fat, cartilage grafting, or fat grafting.
● Skin grafts can be safely re-elevated and undermined within
6 weeks of initial surgery.
23.1 General Principles
The disappointment with skin grafts is their unpredictability
regarding take rate with multiple, sometimes uncontrollable,
factors a ecting their successful take. It should be understood
that unquestionably thicker grafts will oftentimes have a rock-
ier course to final healing, but even duskier poor-appearing
grafts can most frequently go on to heal completely. The inci-
dence of partial graft loss is great, but the incidence of total
graft loss or partial graft loss that requires reoperation is
actually very low.
23.1.1 Initial Postoperative Visit
During the initial postoperative visit, if the graft is dusky or has
poor wound appearance, particularly thicker-appearing grafts,
and if there is a hematoma or seroma, certainly attempt to re-
evacuate it on the initial visit, which is between days 5 and 7.1
This will allow thicker grafts to incorporate and if there is some
superficial slough, it is appropriate to change the antibiotic
ointment to plain Vaseline and allow the patient to shower and
continue simple local wound care. Plan to re-evaluate on a
weekly basis until the graft has declared itself, which may be
several weeks. Even on larger areas of superficial slough, weekly
debridement back to clean healthy bleeding tissue with local
wound care will convert many partial failures on to successful
healing ( Fig. 23.1).
23.1.2 Unacceptable Color Match or
Scar Contour
If the graft heals with unacceptable color and scar formation,
then simple scar management techniques that include dermab-
rasion at 6-week intervals or even injection with Kenalog are
appropriate for management.2,3,4 For full-thickness grafts that
heal with significant depression, it is realized that these can be
re-elevated, even over 100% of their perimeter, and then at
6-week intervals, the contour deformity can be addressed with
either a dermal fat graft or fat injection to improve the final
contour.5,6 Understand that slight overcorrection with dermal
fat will be required and significant overcorrection with fat
grafting may also be required. For full-thickness skin grafts that
heal thickly with fuller contour, silicone sheeting begun at
6 weeks and then periodic fairly low-dose Kenalog injection
with multiple episodes over a period of 3 months can provide
adequate final contour.2,7 Alternatively, after 3 months, grafts
can be re-elevated, thinned, and contoured, and inset to
improve the final contour. Mismatched color on full-thickness
grafts can best be managed with both initial dermabrasion and
laser therapy as illustrated.2,4
23.1.3 Dermabrasion
Dermabrasion is an exceedingly useful adjunct for improving
the appearance of scars, full-thickness grafts, and flaps. Most
patients are o ered dermabrasion beginning at no less than
6 weeks postoperatively. The procedure is done in the clinic uti-
lizing a cylindrical diamond bur and a dedicated dermabrasion
hand power tool. Topical anesthetic is utilized with no infiltra-
tion of local anesthetic. The dermabrasion is performed to deep
punctate bleeding, often called paprika bleeding, and after der-
mabrasion, the resulting wound is given a single application of
triple antibiotic ointment and then the patient is instructed to
stay out of the shower for 1 day and then follow up with 3 to
5 days of petroleum-based ointment until healing. The patient
is cautioned to avoid significant sun exposure 3 to 6 months
postoperatively after dermabrasion. Dermabrasion is o ered at
6-week intervals, usually for no more than three times. Under-
stand that dermabrasion has no e ect on significant contour
Fig. 23.1 A 56-year-old female patient with marginal initial appearance
of skin graft 5 days postoperatively. No additional treatment was
required and the graft healed without incident, as shown 5 months
postoperatively. This is not an unusual occurrence.
Management of Complications and Revisions
192
Fig. 23.2 A 49-year-old male 6 months status
post color-matched full-thickness skin graft from
scalp donor site for 2-cm Mohs resection at nasal
tip. He complained of poor graft contour. He had
graft re-elevated over 60% of its maximal volume
and dermal fat graft placed underneath the
original full-thickness skin graft. Final
postoperative results shown at 2 months.
Fig. 23.3 A 72-year-old male status post inappropriate skin graft done outside of UTSW to repair left alar defect. He complained of poor graft site
contour and nasal airway collapse. Alar rim was reconstructed with conchal cartilage graft and scar excision. Final postoperative results shown at
2 weeks.
Fig. 23.4 A 59-year-old female status post skin graft to left nasal tip. She complained of contour deformity. She was treated with scar excision and
re-elevation and inset of graft. Final postoperative results shown at 4 months.
Skin Graft Revisions
193
abnormalities. It is particularly e cacious in improving small
incision line roughness or contour abnormalities and is particu-
larly e ective at improving final color on hyperpigmented full-
thickness skin grafts.8,9,10,11,12
Dermabrasion is also routinely performed in the operating
room. It is performed on most forehead flap donor sites, as well
as routinely performed on inset of all nasolabial flaps. This
occurs at approximately 3 to 4 weeks postoperatively and the
same procedure is performed with the exception that local
injection is injected along the incision line to be dermabraded.
The majority of dermabrasion performed in the operating room
is performed with a sterile Bovie scratch pad folded in half and
again is performed to deep punctate bleeding. It is actually our
preference to use a Bovie scratch pad over a hand-powered tool
for dermabrasion given that we feel it is safer and delivers more
predictable results. Unfortunately, patients are uniformly
underwhelmed to have Bovie scratch pad dermabrasion as an
awake clinic procedure.
Great care and caution should be utilized when using the
power dermabrasion device because it can be associated with
significant soft-tissue trauma if it abrades an eyelid or lip, for
example. Also, it is incumbent upon the assistant to not place
any gauze within the proximity of the dermabrader because if
it becomes entangled in the cylindrical tip, it is a significant
hazard that can lead to corneal abrasion ( Fig. 23.2, Fig. 23.3,
